Mastermind: Determining the Optimal Dose from Preclinical Studies

Time: 2:00 pm
day: Post-Conference Discussion Day - Track B


Accurately extrapolating the correct dose to go on to use in first in human trials is always a challenge in translational development, but in gene therapy the stakes are very high given the ‘one and done’ paradigm behind so many gene therapies and the very low likelihood of redosing. This mastermind will delve into dosing challenges across:

  • Comparative dosing in different animal models
  • Systemic vs local dosing