Case Studies of Resolving AAV Aggregation & Removing Empty Vectors
Time: 12:00 pm
day: Manufacturing - AM
Details:
- Case study one: aggregation occurring prior to the polishing chromatography step during final UFDF formulation and how this was resolved
- Case study two: novel purification to remove empty capsids – impurities potentially inducing an adverse immune response
- Outlining Fronter’s novel purification platform, removing empty capsids to <1% in the final drug substance