Case Study: Advancing AAV Gene Therapy Vector Generation in Retina & CNS using ML-Guided scAAVengr-HUnT Platform
Time: 12:00 pm
day: Day 2- translation 1
Details:
• Leveraging our previous single cell-based scAAVengr pipeline, Avista created a new High, Unbiased Throughput (scAAVengr-HUnT) platform, modified to develop and test highly complex libraries of novel AAV variants
• Avista’s Machine Learning (ML) model can design novel packaging-efficient libraries in unexplored sequence space
• We utilize our ML-Guided scAAVengr-HUnT platform to rapidly engineer efficient AAV vectors with maximized therapeutic value for multiple different tissues, such as retina and CNS
