Case Study: Rational Engineering of a Hybrid Parvovirus Vector Shows Enhanced Tropism for Muscle Cells while Maintaining its Natural Liver Evasion
Time: 2:00 pm
day: Day 1- Clinical 2
Details:
• Strategies for reducing therapeutic doses to minimize liver toxicity without compromising efficacy
• Exploring novel capsid designs with enhanced tropism and specificity to target cells more effectively, reducing off-target effects and required doses
• Utilizing directed evolution, machine learning, and synthetic biology to create optimized viral vectors for safer and more efficient gene delivery
